ULTRASONOGRAPHIC FEATURES OF THE PELVIC ORGANS IN YOUNG WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
Undifferentiated connective tissue dysplasia (UCTD) results in disruptions in the formation of connective tissue across various organs and systems. Among the disorders associated with this syndrome, recent research has increasingly focused on reproductive system dysfunctions, which present a significant medical issue.
Purpose: To investigate the ultrasound characteristics of the pelvic organs in young women with undifferentiated connective tissue dysplasia.
MATERIALS AND METHODS.
The study was conducted at the clinical base of the Department of Obstetrics, Gynecology, Pediatric Gynecology and Medical Genetics of KhNMU. A total of 70 young women were examined, divided into two clinical groups. The first clinical group (main group, MG) consisted of 50 patients with undifferentiated connective tissue dysplasia (UCTD), while the second clinical group (control group, CG) included 20 somatically healthy young women. Both groups sought routine pre- ventive check-ups. All participants provided written informed consent for the use of their findings for scientific purposes in accordance with the ethical principles of the Helsinki Declaration of the World Medical Association (latest revision). UCTD was diagnosed based on phenotypic characteristics and the level of 5-hy- droxyproline in urine. Ultrasound examination (US) of the pelvic organs (PO) was performed using the MINDRAY M7 ultrasound scanner (China). During the US of the PO, the size of the uterus and cervix, the structure of the myometrium, thickness and echostructure of the endometrium, and the condition of the ovaries were assessed. Statistical data processing was performed using the general-purpose software package Statistica 6.0.
RESULTS AND DISCUSSION.
In the CG patients, no ultrasound changes in the pelvic organs were detected. In the MG, the following changes were observed: uterine hypoplasia in 10 (20%) patients, retroversion of the uterus in 12(24%) patients, saddle-shaped uterus in 8(16%) patients, bicornuate uterus in 5 (10%) patients, duplicated uterus in 1(2%) patient, unicornuate uterus in 2(4%) patients, and multifollicular changes in the ovaries in 17(34%) patients. Additionally, 11(22%) patients showed a combination of multifollicular ovaries with uterine abnormalities.
CONCLUSIONS.
US of the PO in young women with undifferentiated connective tissue dys- plasia (UCTD) revealed a high frequency of structural changes in the uterus and ovaries, suggesting the influence of UCTD on the development of the reproductive system. The detected uterine malformations and multifollicular ovarian changes may have clinical significance and could lead to reproductive health issues in this group of patients. The findings underscore the need for comprehensive examina- tion and dynamic monitoring of women with UCTD for the early diagnosis of potential reproductive complications.
Purpose: To investigate the ultrasound characteristics of the pelvic organs in young women with undifferentiated connective tissue dysplasia.
MATERIALS AND METHODS.
The study was conducted at the clinical base of the Department of Obstetrics, Gynecology, Pediatric Gynecology and Medical Genetics of KhNMU. A total of 70 young women were examined, divided into two clinical groups. The first clinical group (main group, MG) consisted of 50 patients with undifferentiated connective tissue dysplasia (UCTD), while the second clinical group (control group, CG) included 20 somatically healthy young women. Both groups sought routine pre- ventive check-ups. All participants provided written informed consent for the use of their findings for scientific purposes in accordance with the ethical principles of the Helsinki Declaration of the World Medical Association (latest revision). UCTD was diagnosed based on phenotypic characteristics and the level of 5-hy- droxyproline in urine. Ultrasound examination (US) of the pelvic organs (PO) was performed using the MINDRAY M7 ultrasound scanner (China). During the US of the PO, the size of the uterus and cervix, the structure of the myometrium, thickness and echostructure of the endometrium, and the condition of the ovaries were assessed. Statistical data processing was performed using the general-purpose software package Statistica 6.0.
RESULTS AND DISCUSSION.
In the CG patients, no ultrasound changes in the pelvic organs were detected. In the MG, the following changes were observed: uterine hypoplasia in 10 (20%) patients, retroversion of the uterus in 12(24%) patients, saddle-shaped uterus in 8(16%) patients, bicornuate uterus in 5 (10%) patients, duplicated uterus in 1(2%) patient, unicornuate uterus in 2(4%) patients, and multifollicular changes in the ovaries in 17(34%) patients. Additionally, 11(22%) patients showed a combination of multifollicular ovaries with uterine abnormalities.
CONCLUSIONS.
US of the PO in young women with undifferentiated connective tissue dys- plasia (UCTD) revealed a high frequency of structural changes in the uterus and ovaries, suggesting the influence of UCTD on the development of the reproductive system. The detected uterine malformations and multifollicular ovarian changes may have clinical significance and could lead to reproductive health issues in this group of patients. The findings underscore the need for comprehensive examina- tion and dynamic monitoring of women with UCTD for the early diagnosis of potential reproductive complications.
